Manual of histologic stainig methods of the armed forces institute of pathology 3rd ed. Role of bovine herpesvirus type 5 bohv5 in diseases of cattle. Rinotraqueitis bovino infeccioso ibr y vulvovaginitis pustular infecciosa ipv en hembras y balanopostitis pustular infeccioso ipb en machos. Even though both are neurotropic viruses, only bohv5 is capable of replicating extensively. Fetal lesions are typical of herpesvirus infection in other species and include multifocal necrosis and hemorrhage see previous discussion. The second is a generalized cutaneous form named allerton disease or pseudolumpy skin disease, due to its similarity with the. Bovine herpesvirus2 affects the teats and udders of cows as well as the perineum in some cases and occasionally the mouths and muzzles of suckling calves.
Aspects of bovine herpesvirus 5 bohv5 pathogenesis and experimental therapies against bohv1 and bohv5 were investigated in vitro and in inoculated rabbits. Bovine herpes virus type 1 bohv1 as a possible cause of. Then, the chapter discusses the transmission and pathogenesis of the virus, which are very important as they help to control the virus. Detection of bovine herpesvirus 1 and 5 in trigeminal ganglia of beef cattle in uruguay. Bovine herpesvirus, characterisation of strains, rabbit model. Retrospective study of bovine herpesvirus 5 meningoencephalitis in. Bovine alphaherpesvirus 2 bohv2 is a virus of the family herpesviridae that causes two diseases in cattle, bovine mammillitis and pseudolumpy skin disease.
Bovine herpesvirus1 bhv1 is known to cause several diseases worldwide. Two inoculated steers had clinical signs of pem after 118 and 146 days after virus. February development of an indirect elisa for serological diagnosis of bovine herpesvirus 5 luana a. This virus can infect a wide range of species, either in vivo or in vitro. This work revises the infections caused by bovine herpesvirus 1 bohv1 and its implications on the reproduction of cattle, as its most expressive productive losses are related to the repeating breeding, abortions, and the birth of weak or stillbirth calves due to the infection. The aim of this study was to determine the presence of bovine herpesvirus 1 bohv. Herpesvirus bovino tipo 5 bhv5 em bovino infectado pelo virus da raiva. Most abortions associated with bhv1 occur during the second half of gestation. It includes the detailed etiology of the infection, discussing the virus characteristics, virus structure, genome, viral proteins, types and subtypes of the virus. During latency there is a dramatic reduction of viral gen expression. Gliomas are considered among the most puzzling problems of medicine due to the complexity of their anatomic localization, and the lack of a real therapeutic treatment. Role of bovine herpesvirus type 5 bohv5 in diseases of. Bovine herpesvirus 4 bohv4 is tropic for bovine endometrial cells and modulates endocrine function.
Although ks mainly affects the skin, the mouth, and the lymph nodes, it can also involve the bowels and lungs. Development of an indirect elisa for serological diagnosis. Fetal autolysis is usually present because of rapid death of the fetus. Pdf encefalitis bovina por herpesvirus bovino tipo 5. Infectious bovine rhinotracheitis, animal health, abortion. Bovine herpesvirus type 5 bohv5 is a major causative agent of. Bovine herpesvirus 2 bhv2 is the causative agent of two diseases. Animals latently infected with bhv1 are potential sources of bhv1 infection since the reactivated virus in the tg can be transported back to the noseeye to be shed in nasal and ocular secretions. Directional spread of bovine herpesvirus type 1 bhv1. Herpes simplex virus type 1 and bovine herpesvirus 1 latency. Bovine herpesvirus 1 an overview sciencedirect topics. Both names bohv1 and ibr are currently in common use. Foster, in pathologic basis of veterinary disease sixth edition, 2017. Infeccoes por herpesvirus bovino tipo 1 bohv1 e suas.
Bovine herpesvirus 1 bohv1 is a sporadic cause of bovine abortion. Bovino 1 taise maria dos anjos oliveira orientador. Among these diseases, those of viral origin are dangerous, since their rapid spread causes great economic damages. Meningoencephalitis caused by bovine herpesvirus5 bohv5 is an often fatal, acute or subacute infectious disease that affects mainly young cattle under stressing conditions. Kaposis sarcoma is a type of cancer that affects men and is rarely seen in women. Bhv5, which is closely related to bhv1, causes severe neurological disease in calves. Bovine herpesvirus 1 abbreviated to bohv1, bhv1 or bhv1 is the official species name of the virus. The present study investigated the presence of bohv5 dna in cattle. This virus is a major causative agent of nonsuppurative meningoencephalitis in young cattle. Latency of bhv1 and hsv1 is established in sensory neurons of trigeminal ganglia, but latency can be interrupted periodically, leading to reactivation from latency and spread of infectious virus. Infectious bovine rhinotracheitis virus ibr virus is an alternative name ictv 2002.
Bovine herpesvirus1 bhv1, disease called infectious bovine rhinotracheitis or ibr is associated with bovine respiratory disease, vulvovaganitis, balanoposthitis, conjunctivitis, and abortion. Encefalitis bovina por herpesvirus bovino tipo 5 hvb5. Bovine herpesvirus how is bovine herpesvirus abbreviated. Cytomegalovirus del bovino e del cavallo, rinite a corpi inclusi suino, ecc gammaherpesvirinae. Reactivation of latent bovine herpesvirus type 5 in cattle with. The first is localized in the udder and called bovine herpes mammillitis. Use of real time polymerase chain reaction to detect. Manual of diagnostic tests and vaccines for terrestrial animals.
It was first isolated in 1962 from a neurological disease outbreak in australia. Herpesvirus canino chv, rinotracheite virale infettiva felina, ecc betaherpesvirinae. Bovine herpesvirus 1 bhv1 has similar biological properties to hsv1 and is a significant health concern to the cattle industry. This is the first report of a mixed rabies bhv5 infection in calves. Herpesvirus bovino 1 bhv1 rinotraqueite infecciosa bovina taxonomia biswas s, bandyopadhyay s, dimri u, patra ph. Bohv1 in cattle results in a wide range of clinical manifestations, such as infectious bovine rhinotracheitis, abortion and infectious pustular vulvovaginitis. It can also causes generalised disease in rare cases and lead to pseudolumpy skin disease. Bovine herpesvirus type 5 bohv 5 belongs to the family herpesviridae, subfamily alphaherpesvirinae, genus varicellovirus. Different prototypes of herpesviridae, host range, and their associated. Bohv1 is also a contributing factor in shipping fever, also known as bovine respiratory disease brd. The main topic of this work concerns the possibility to use bovine herpesvirus type 4 bohv4 as a vector for gene therapy for the treatment of glioma, and that the campdependent protein kinases pka pathway as a possible.